Paramyxoviruses



MMR Vaccine

Composition: Live attenuated virus. Measles: Schwartz or Moraten substrains of Edmonston B strain. Mumps: Jeryl Lynn strain. Rubella: RA/27-3 strain. Vaccination schedule: at 12-15 months and again at 4-6 years or before middle school. Efficiency: 95% lifelong immunization with a single dose.

Measles Virus

Measles virus is a member of the genus Morbillivirus within the family Paramyxovirus. Measles virus differes from other members of the family in that it lacks neuraminidase. There is only one measles serotype, so recovery from natural infection confers lifelong immunity. Measles is one of five childhood exanthems, the others being rubella, varicella, roseola and [...]

Mumps Virus

Mumps virus is a member of the genus Paramyxovirus. It causes distinctive and generally benign system infections characterized by fever and parotitis (parotid inflammation, a salivary gland below the ear). Epidemiology It is a disease of school-aged children worlwide. In unvaccinated populations, 92% of children have antibodies by age 15. A mumps vaccine was licensed [...]

Respiratory Syncytial Virus

Respiratory syncytial virus fuses membranes together to make enormous cells (fused aggregates). These aggregates get into alveoli of the lower respiratory tract, and the patient has trouble breathing out. It is more invasive than parainfluenza virus, as it goes deeper into the lungs, and is responsible for a lot of infant pneumonia. There is no [...]

Parainfluenza Virus (PIV)

It has only one RNA segment, meaning all genetic information is in one long RNA strand. It is an enveloped virus, which makes it very unstable. These envelopes are part of the cell membrane of the mamallian cell. The wall is unstable and easily dissolved, unlike polio which has a protein capsid and is very [...]