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Immunology Probes


Written by      First published December 7, 2008      Last modified August 29, 2011

Probe Overview
Ig DNA Unrearranged DNA shows as a single line. Rearranged DNA shows as a smear.
I mRNA When T cell help ( CD40-CD40L) interaction occurs there is DNA rearrangement such that VH is joined to Cε; Iε is removed from the genome and the mRNA no longer contains it. If I mRNA is not excised, but nonfunctioning immunoglobulin is still produced, then cytokine receptors are functioning but CD40/CD40L interaction is askew.

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