Mitosis factors
By Levi Clancy for Student Reader on
updated
| Factor | Overview |
|---|---|
| E2F | E2F is a transcription factor that by itself activates transcription. |
| Rb | Rb binds to E2F and represses its activation function. Rb is deactivated upon phosphorylation by mid G1 cyclin-CDKs (and, eventually, late G1 cyclin-CDKs). |
| Cohesin | Cohesin is a heterotrimeric complex of Smc1, Smc3 and Kleisin (Scc1). Smc1 and Smc3 form a circle that is clasped together by Kleisin. This ring fits over the chromatin near the centromere, remaining snugly over the sister chromatids after DNA replication. |
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