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Phage lytic cycleComments

Phage lytic cycle

Virion coat proteins absorb to specific receptors on host cell surface.

This give the virus specificity, meaning that it will only be able to infect a certain host range. Once the viral genome is injected into the cell, then for a DNA phage, bacterial cell's RNAP begins transcribing RNAs from certain promoters. The first class of viral genes is intermediate-early genes. Following translation of these genes, the early viral genes are transcribed. These genes encode proteins which get virus ready for DNA replication.

After DNA replication, usually into hundreds of copies, the late viral RNAs are made and translated into proteins. These act as structural components, either for capsid formation or cleaving and packaging of DNA into capsid, or to form the receptor on the capsid surface.

Nucleocapsid:

  • Attachment
  • Fusion & entry into the cytoplasm

Viral Envelope:

  • Attachment
  • Endocytosis
  • Endocytic vessicle (low pH)
  • Fusion & entry into the cytoplasm

Plasma-Membrane:

  • Attachment
  • Endocytosis
  • Endocytic vessicle (low pH)
  • Membrane penetration & entry into the cytoplasm