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Mitosis: Cell Cycle Activators

By Levi Clancy for Student Reader on

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CAK KinaseCyclin-CDKsCAK positive phosphorylates CDK1, CDK2 and CDK4. CAK is itself a member of the CDK family and is composed of CDK7, cyclin H and an assembly protein Mat1. Checkpoint controls, inactivate Cdc25C and Cdc25a phosphatases to induce cell-cycle arrest. (link)
Cdc25 phosphataseCyclin-CDKsInvolved in activating MPF.
Cdc25a phosphataseS-phase Cyclin-CDKActivates vertebrate S-phase cyclin-CDK
Cdc25c phosphataseMitotic Cyclin-CDKActivates vertebrate mitotic cyclin-CDK
Cdc14 phosphataseCdh2Activating Cdh2 thus inhibits mitotic cyclin-CDK
ATM/ATR KinasesChk1/Chk2Checkpoint controls, activate Chk1/Chk2 kinases