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MotilityComments

Motility

Cells move to find food, shelter and safety.
FlagellatedFlagella are polar, bipolar, lophotrichous (bunch at 1 end), monotrichous, amphitricious and petrichous (E. coli). To view with high contrast, use die, electric microscope, or dark field. Help w/ attachment.
  • cilia
  • lophotrophs
  • polar
  • bilpolar
Random WalkCells move toward attractants (c-source), from repellent (organo acid) and indifferently to control (media). Requirements are (a) sense external signal, (b) respond to signal (internal signal), (c) modify behavior and (d) scalable response. E. coli: Tumble, run, tumble. Tumble every 10th sec, run 10 secs, T req of both 13 /sec. Random walk. The random walk is biased. As concentration of attractant goes up, the tumble frequency goes down. E. coli run ccw (bundle) and then unbundle and go cw to tumble. When the attractant concentration is high, the cw frequency goes down, unbundled is less likely to occur, and running (ccw) happens more often. Is the propellor or the whip model correct? Howeder saw that flagellum spin ccw, stop, cw, stop, ccw, etc. Algae is a good model organism for studying motility. Cilia are on protozoans (paramecium). Microtubule-based, extend from basal body, surrounded by cell membrane, mechanism=sliding & bending of microtubules. Running is more often in presence of attractant.
Ameboid MotionExtend pseudopod...mechanism: actin, controlled polymerization of actin filaments at leading edge pseudopod....used by entamoeba protozoan for dyssentary, slime molds.
Gliding MotilitySmooth gliding with no apparent change in cell morphology. Example: toxoplamsagondii (very important)...malaria plasmoduan. Gliding motility somehow involves actin. Demonstrate via mutation to actin.