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Also known as the testes-determining gene or sex-determining region on the Y chromosome, SRY is a gene located on the short arm of the Y chromosome and encodes a DNA-binding transcription factor known as testes-determining factor (TDF) early (and briefly) in development. Although SRY does not determine sex in all cases -- it is not present in 10% of unambiguous XX males -- it is a key instrument in the concert of sex determination.