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Inflammatory response

The inflammatory response is characterized by the following three events
  1. Vasodilation. Vasodilation is an increase in blood vessel diameter.
  2. Permeability. Capillaries increase in permeability, allowing exudate to flow to and swell the site of inflammation.
  3. Phagocyte influx. An influx of phagocytes consists of three steps: margination, where phagocytes adhere to the capillary endothelium; extravasation, where phagocytes exit the capillaries; and chemotaxis, where phagocytes migrate towards the area of inflammation.
Soluble mediators involved in the inflammatory response
  1. Acute phase proteins. Released by the liver, acute phase proteins bind polysaccharides and initiate the complement cascade.
  2. Histamine. Released in response to injury, histamine leads to vasodilation and increased capillary permeability.
  3. Kinins. Also released in response to injury, kinins lead to vasodilation, an increase in capillary permeability and stimulation of skin pain receptors.
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