Relative Risk
By Levi Clancy for Student Reader on
updated
- Parent
- Siblings
- Androgen Insensitivity
- Balanced Rearrangement
- Cancer genetics
- Chromosome Number Abnormalities
- Cystic Fibrosis
- Down Syndrome
- Duchenne Muscular Dystrophy
- Fragile X Syndrome
- Hemoglobinopathy
- Huntington Disease
- Hurler Syndrome
- Hyperphenylalaninemia
- mRNA Splicing Aberrations
- Nondisjunction
- Penis-At-Twelve Syndrome
- Sickle Cell Disease
- Spinal Muscular Atrophy
- Tay-Sachs Disease
- Thalassemia
- Triplet Repeat Expansions
- Trisomy 13
- Trisomy 18
- Unbalanced Rearrangement
- Uniparental Disomy
λr = (prevalence of disease in relatives of an affected person) / (prevalence of disease in the general population)
Relative Risk (λr) is one measure (along with case-control studies) for measuring familial aggregation. Familial aggregation (clustering of a disease within a family) is a characteristic of diseases with complex inheritance. λr can be adapted for siblings (λr=s) or parents (λr=p).