Central dogma
By Levi Clancy for Student Reader on
updated
- Parent
- Siblings
- Chi-squared test
- Darwinian Evolution
- Evolutionary agents
- Gene
- Gene regulation
- Genetic and phenotypic variation
- Genetic code
- Genetic disease
- Genetics and Genomics Questions
- Genomic imprinting
- Genomics
- Hardy-Weinberg equilibrium
- Homeodomain
- Human genetics
- Insertion sequence elements
- Lac Operon
- Linkage analysis
- LOD Score
- Mendel's Laws of Genetics
- Mutation
- Polymorphism
- Sex
- SRY
- Subpages
The central dogma refers to the flow of genetic information: DNA →transcription→ RNA →translation→ Protein; and DNA → replication → DNA. Polynucleotide synthesis (transcription and replication) in all cells proceeds in the 5’ - 3’ direction for both RNA and DNA. This is because the precursors are 5’-nucloeside triphosphates and the free 5'-phosphate is subjected to a nucleophilic attack by the 3’-OH group of the growing polynucleotide chain.