By Levi Clancy for Student Reader on
Pyruvate decarboxylation (aka oxidative decarboxylation) is not a reaction of glycolysis, but is very common in most organisms as a link to the citric acid cycle.
In pyruvate decarboxylation, pyruvate is bonded to Coenzyme A (CoA) to form Acetyl CoA. Acetyl CoA is trapped in the mitochondria. This step is much like the phosphorylation of glucose in the first step of the glycolysis; however, pyruvate decarboxylation occurs in mitochondria, unlike the cytosolic reactions of glycolysis.