Multi-Drug Resistant Protein

By Levi Clancy for Student Reader on
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Multidrug resistant protein (MDR) is a ~170 kDa P-glycoprotein that confers drug resistance. It is overproduced and targeted to the vacuole membrane where it inserts using 12 transmembrane domains to form a pore. It can bind many classes of drugs and pump them out using its own ATPase domain to drive the reaction.