Multi-Drug Resistant ProteinComments
siblingsAntibioticsBacterial ParasitesDiagnosing Infectious DiseaseIntracellular pathogensPrionsProtozoan ParasitesVirulence Factor

Multi-Drug Resistant Protein

Multidrug resistant protein (MDR) is a ~170 kDa P-glycoprotein that confers drug resistance. It is overproduced and targeted to the vacuole membrane where it inserts using 12 transmembrane domains to form a pore. It can bind many classes of drugs and pump them out using its own ATPase domain to drive the reaction.